Nucleoside derivatives are well represented as pharmaceuticals due to their drug like physicochemical properties, and some nucleoside drugs are designed to act on receptors. Through methanocarba nucleoside synthesis, structure–activity relationships, and multi-target pharmacology, a robust purinergic receptor scaffold has been repurposed to satisfy the pharmacophoric requirements of various GPCRs, enzymes and transporters.
Speaker: Professor Kenneth A Jacobson
Molecular Recognition Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD, 20892, USA.
kennethj@niddk.nih.gov
Hosted by Prof. Anna Maria Pugliese
2 Settembre 2024 ore 14.30 presso Dipartimento Neurofarba Aula EX BIBLIOTECA
